A number of trials have been done to determine the safety of these various forms of HRT but a conclusive decision has not been reached yet. Therefore, it is important to determine which form of estrogen replacement is safer to overcome postmenopausal symptoms in women as postmenopausal symptoms are very common and can be very disturbing and disabling for a lot of women.
The purpose of this study is to compare the effects of oral and intravaginal estrogen to preserve vaginal integrity and treat vaginal dryness and atrophy. This study also intends to compare the safety of long term use of oral and intravaginal estrogen.
All the postmenopausal women with vaginal dryness and atrophy requiring HRT during the study period will be included in the study. Patients in whom HRT is contraindicated will not be included in the study as this can be a major confounding factor in the study results.
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